~Teachingcenter的醫學筆記~

細胞激素及其受器(MCP、MIP、RANTES、LARC…)
Cytokines and its Receptors (MCP、MIP、RANTES、LARC…)

MCP-1 (monocyte chemoattractant protein-1)

1. Receptor
   • CCR2
2. Cell source
   • Fibroblasts
   • Smooth muscle cells
   • Activated peripheral blood mononuclear cell (PBMCs)
3. Cell target
   • Monocytes/macrophages
   • NK cells
   • Memory T cells
   • Basophils
4. Biologic activity
   • Chemoattractant for monocytes, activated memory T cells, and NK cells
   • Induces granule release from CD8⁺ T cells and NK cells
   • Potent histamine-releasing factor for basophils
   • Suppresses proliferation of hematopoietic precursors
   • Regulates monocyte protease production

MCP-2

1. Receptor
   • CCR1
   • CCR2
2. Cell source
   • Fibroblasts
   • Activated PBMCs
3. Cell target
   • Monocytes/macrophages
   • T cells
   • Eosinophils
   • Basophils
   • NK cells
4. Biologic activity
   • Chemoattractant for monocytes, activated memory T cells, eosinophils, and NK cells.
   • Activates basophils and eosinophils
   • Regulates monocyte protease production

MCP-3

1. Receptor
   • CCR1
   • CCR2
2. Cell source
   • Fibroblasts
   • Activated PBMCs
3. Cell target
   • Monocytes/macrophages
   • T cells
   • Eosinophils
   • Basophils
   • NK cells
   • Dendritic cells
4. Biologic activity
   • Chemoattractant for monocytes, activated memory T cells, eosinophils, and NK cells.
   • Activated basophils and eosinophils
   • Regulates monocyte protease production

MCP-4

1. Receptor
   • CCR2
   • CCR3
2. Cell source
   • Lung, colon, and small intestinal epithelial cells
   • Activated endothelial cells
3. Cell target
   • Monocytes/macrophages
   • T cells
   • Eosinophils
   • Basophils
4. Biologic activity
   • Chemoattractant for monocytes, T cells, eosinophils, and basophils

Eotaxin

1. Receptor
   • CCR3
2. Cell source
   • Pulmonary epithelial cells
   • Heart
3. Cell target
   • Eosinophils
   • Basophils
4. Biologic activity
   • Potent chemoattractant for eosinophils and basophils
   • Induces allergic airways disease
   • Acts in concert with IL-5 to activate eosinophils
   • Antibodies to eotaxin inhibit airway inflammation

TARC (thymus- and activation-regulated chemokine)

1. Receptor
   • CCR4
2. Cell source
   • Thymus
   • Dendritic cells
   • Activated T cells
3. Cell target
   • T cells
   • NK cells
4. Biologic activity
   • Chemoattractant for T and NK cells

MDC (macrophage-derived chemokine)

1. Receptor
   • CCR4
2. Cell source
   • Monocytes/macrophages
   • Dendritic cells
   • Thymus
3. Cell target
   • Activated T cells
4. Biologic activity
   • Chemoattractant for activated T cells
   • Inhibits infection with T cell tropic HIV

MIP-1α (macrophage inflammatory protein)

1. Receptor
   • CCR1
   • CCR5
2. Cell source
   • Monocytes/macrophages
   • T cells
3. Cell target
   • Monocytes/macrophages
   • T cells
   • Dendritic cells
   • NK cells
   • Eosinophils
   • Basophils
4. Biologic activity
   • Chemoattractant for monocytes, T cells, dendritic cells, and NK cells
   • Weak chemoattractant for eosinophils and basophils
   • Activates NK cell function
   • Suppresses proliferation of hematopoietic precursors
   • Necessary for myocarditis associated with Coxsackie virus infection
   • Inhibits infection with monocytotropic HIV

MIP-1β

1. Receptor
   • CCR5
2. Cell source
   • Monocytes/macrophages
   • T cells
3. Cell target
   • Monocytes/macrophages
   • T cells
   • NK cells
   • Dendritic cells
4. Biologic activity
   • Chemoattractant for monocytes, T cells, and NK cells
   • Activates NK cell function
   • Inhibits infection with monocytotropic HIV

RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted)

1. Receptor
   • CCR1
   • CCR2
   • CCR5
2. Cell source
   • Monocytes/macrophages
   • T cells
   • Fibroblasts
   • Eosinophils
3. Cell target
   • Monocytes/macrophages
   • T cells
   • NK cells
   • Dendritic cells
   • Eosinophils
   • Basophils
4. Biologic activity
   • Chemoattractant for monocytes/macrophages, CD4⁺, CD45Ro⁺ T cells, NK cells, eosinophils, and basophils
   • Induces histamine release from basophils
   • Inhibits infections with monocytotropic HIV

LARC/MIP-3α/Exodus-1
(liver activation regulated chemokine)

1. Receptor
   • CCR6
2. Cell source
   • Dendritic cells
   • Fetal liver cells
   • Activated T cells
3. Cell target
   • T cells
   • B cells
4. Biologic activity
   • Chemoattractant for lymphocytes

ELC/MIP-3β
(EBI1 ligand chemokine)

1. Receptor
   • CCR7
2. Cell source
   • Thymus
   • Lymph node
   • Appendix
3. Cell target
   • Activated T cells and B cells
4. Biologic activity
   • Chemoattractant for B and T cells
   • Receptor upregulated on EBV-infected B cells and HSV-infected T cells