|
Type |
Marker |
Half-life |
Cancer or other |
|
Hormone |
Calcitonin |
12 min |
Thyroid medullary carcinoma |
|
β-HCG |
18~24 hr |
Germ cell tumor or GTD* |
|
|
Tumor associated protein |
PSA |
2~3 days |
Prostate cancer, BPH, prostatitis |
|
CA125 |
4~5 days |
Ovarian cancer, menses, peritonitis |
|
|
CA153 |
<2 weeks |
Breast cancer |
|
|
CA199 |
14 hr |
Pancreatic cancer, pancreatitis |
|
|
Oncofetal antigen |
α-fetoprotein |
3~6 days |
Hepatic carcinoma, testis cancer, cirrhosis, hepatitis |
|
CEA |
2 weeks |
Adeno^, smoking, bronchitis |
|
|
Other |
β-microglobulin |
80 min |
MM, MGUS” , infection |
|
Thyroglobulin |
weeks |
Thyroid follicular carcinoma |
*GTD = Gestational trophoblastic disease
^Adeno = adenocarcinoma (especially colon)
“MM = Multiple myeloma
“MGUS = Monoclonal gammopathy of uncertain significance
節選自First choice
腫瘤指標tumor marker有以下功能：
1.在無症狀之族群篩檢出早期癌症
2.診斷癌症
3.判斷預後
4.監測抗癌治療的反應
5.偵測癌症復發
使用腫瘤指標的優點：
1.造成病人的不便與傷害小
2.可以短時間內大量檢測
3.判讀客觀
4.相對價格便宜
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醫學筆記-小兒外科 (3)