不同自體免疫疾病中的抗核抗體
Antinuclear Antibodies in Various Autoimmune Diseases

抗體

陽性比率(%) (percentage of positive result in different diseases)

Systemic LE

Drug-induced LE

SSD

LS (CREST)

SS

IM

Generic ANA

>95%

>95%

70~90%

70~90%

50~80%

40~60%

Anti-dsDNA

40~60%

<5%

<5%

<5%

<5%

<5%

Anti-histone

50~70%

>95%

<5%

<5%

<5%

<5%

Anti-Sm

20~30%

<5%

<5%

<5%

<5%

<5%

Nuclear RNP

30~40%

<5%

<5%

10%

<5%

<5%

SS-A(Ro)

30~50%

<5%

<5%

<5%

70~95%

10%

SS-B(La)

10~15%

<5%

<5%

<5%

60~90%

<5%

Scl-70

<5%

<5%

28~70%

10~18%

<5%

<5%

Anti-centromere

<5%

<5%

22~36%

90%

<5%

<5%

Jo-1

<5%

<5%

<5%

<5%

<5%

25%

LE = lupus erythematosus、SSD = systemic sclerosis-diffuse = systemic scleroderma、LS = limited scleroderma = CREST = Calcinosis, Raynaud's syndrome, Esophageal dysmotility, Sclerodactyly, Telangiectasis、SS = Sjögren syndrome、IM = inflammatory myopathies
Many nuclear antigens (DNA, RNA, proteins) → Generic ANA (antinuclear antibodies)
Native DNA → Anti-dsDNA (double-stranded DNA)
Histones → Anti-histone
Core proteins of small nuclear ribonucleoprotein (RNP) particles (Smith antigen) → Anti-Sm
RNP (U1 RNP) → Nuclear RNP
RNP → SS-A(Ro) or SS-B(La)
DNA topoisomerase 1 → Scl-70
Centromeric proteins → Anticentromere
Histidyl-tRNA synthetase →Jo-1

 

antinuclear_antibodies_in_various_autoimmune_disease.PNG

 

 


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