~Teachingcenter的醫學筆記~

常見的致癌基因(common oncogenes)
= ErbB2, neu
--- 乳癌、卵巢癌、胃癌
= Myc
--- 淋巴癌等眾多癌症
= Ret
--- 甲狀腺癌(Medullary carcinoma)
= K-ras
--- 肺癌、大腸癌
= H-ras
--- 膀胱癌
= N-myc
--- 神經母細胞瘤(neuroblastoma)

常見的抑癌基因(common tumor suppressor genes)
= Dcc
--- 大腸癌
= Apc
--- 大腸癌，尤其家族性腺瘤性息肉病(familial polyposis)
= Brac1 and Brac2
--- 乳癌、卵巢癌
= p53
--- 白血病等眾多癌症
= Rb
--- 視網膜母細胞瘤(retinoblastoma)
= WT1
--- 威爾姆氏腫瘤(Wilms tumor)

人類肺癌相關的致癌基因
= EGFR  30~40%
= K-ras   30%
= Myc
--- non-small cell lung cancer: 10%
--- small cell lung cancer: 40%
= Erb2   25%
= BCL2   25%
= ALK   5%

人類肺癌相關的抑癌基因
= 3p chromosome deletion
--- non-small cell lung cancer: 50%
--- small cell lung cancer: 90%
= Rb
--- non-small cell lung cancer: 15%
--- small cell lung cancer: 90%
= p53
--- non-small cell lung cancer: 50%
--- small cell lung cancer: 80%
= p16   60%