細胞激素和趨化素受器Receptors of Cytokines and Chemokines

細胞激素受器cytokine receptors

  1. Type I cytokine (hemopoietin) receptors：IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-9、IL-11、IL-12、IL-13、IL-15、GM-CSF、G-CSF、growth hormone、prolactin
  2. Type II cytokine receptors：IFN-α、IFN-β、IFN-γ、IL-10
  3. TNF receptors：TNF、lymphotoxin (LT)、CD40、Fas、nerve growth factor
  4. Immunoglobulin superfamily receptors：IL-2、M-CSF、stem cell factor

 

趨化素(區劃因子)受器chemokine receptors (seven transmembrane α-helical receptors)

分類

趨化素

分泌細胞

受器

吸引細胞

已知的重要功能

CXC

CXCL8
(IL-8)

Monocytes
Macrophages
Fibroblasts
Keratinocytes
Endothelium

CXCR1
CXCR2

Neutrophils
Naïve T cells

移動、活化、血管新生、嗜中性球去顆粒(degranulates)

CXCL7 (PBP、
β-TG、NAP-2)

Platelets

CXCR2

Neutrophils

活化嗜中性球、吸收血塊、血管新生

CXCL1 (GROα)
CXCL2 (GROβ)
CXCL3 (GROγ)

Monocytes
Fibroblasts
Endothelium

CXCR2

Neutrophils
Naïve T cells
Fibroblasts

活化嗜中性球、血管新生、纖維組織增生(fibroplasia)

CXCL10 (IP-10)

Keratinocytes
Monocytes
T cells
Fibroblasts
Endothelium

CXCR3

Resting T cells
NK cells
Monocytes

抗血管新生、促進T helper 1免疫功能、增強免疫作用(immunostimulant)

CXCL12 (SDF-1)

Stromal cells

CXCR4

Naïve T cells
Progenitor
(CD34+) B cells

B細胞發育、淋巴球歸巢作用、可與HIV-1競爭

CXCL13 (BLC)

Stromal cells

CXCR5

B cells

淋巴球歸巢作用

CC

CCL3 (MIP-1α)

Monocytes
T cells
Mast cells
Fibroblasts

CCR
1, 3, 5

Monocytes
NK and T cells
Basophils
Dendritic cells

與HIV-1競爭、抗病毒作用、促進T helper 1免疫功能

CCL4 (MIP-1β)

Monocytes
Macrophages
Neutrophils
Endothelium

CCR
1, 3, 5

Monocytes
NK and T cells
Dendritic cells

與HIV-1競爭

CCL2 (MCP-1)

Monocytes
Macrophages
Fibroblasts
Keratinocytes

CCR2B

Monocytes
NK and T cells
Basophils
Dendritic cells

活化巨噬細胞、嗜鹼細胞釋放組織胺、促進T helper 2免疫功能

CCL5 (RANTES)

T cells
Endothelium
Platelets

CCR
1, 3, 5

Monocytes
NK and T cells
Basophils
Eosinophils
Dendritic cells

嗜鹼性球去顆粒化、活化T細胞、慢性發炎

CCL11 (Eotaxin)

Endothelium
Monocytes
Epithelium
T cells

CCR3

Eosinophils
Monocytes
T cells

過敏反應

CCL18 (DC-CK)

Dendritic cells

?

Naïve T cells

活化Naïve T cells

C

XCL1
(Lymphotactin)

CD8 > CD4
T cells

CXCR1

Thymocytes
Dendritic cells
NK cells

淋巴球的運送和生長發育

CXXXC
(CX3C)

CX3CL1
(Fractalkine)

Monocytes
Endothelium
Microglial cells

CX3CR1

Monocytes
T cells

作用於白血球和內皮間的黏連分子上、腦部發炎

PBP = platelet basic protein、β-TG = β-thromboglobulin、NAP-2 = neutrophil-activating peptide-2、GRO = growth-regulated oncogene、IP-10 = interferon-γ-inducible protein-10、SDF-1 = stromal cell-derived factor-1、BLC = B lymphocyte chemoattractant、MIP = macrophage inflammatory proteins、MCP = monocyte chemoattractant protein、RANTES = Regulated upon Activation, Normal T cell Expressed, and Secreted、DC-CK = dendritic cell chemokine
Figure2-46 Immunobiology, 7ed. (© Garland Science 2008)

 

淋巴球歸巢(lymphocyte homing)：
是指淋巴球的定向遊動，包括淋巴幹細胞向中樞淋巴器官歸巢，成熟淋巴球向外周淋巴器官歸巢，淋巴球再循環，以及淋巴球向炎症部位遷移。其分子基礎是淋巴球歸巢受體與內皮細胞上地址素(addressin)之間的相互作用

※黏膜地址素细胞黏附分子(mucosal addressin cell adhesion molecule-1, MAdCAM-1)

 

chemokine_receptors.PNG


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