~Teachingcenter的醫學筆記~

細胞激素及其受器(TCA、DC-CK、GRO、MIG…)
Cytokines and its Receptors (TCA、DC-CK、GRO、MIG…)

I-309/TCA-3
(T cell activation-3, TCA-3)

1. Receptor
   • CCR8
2. Cell source
   • Activated T cells
3. Cell target
   • Monocytes/macrophages
   • T cells
4. Biologic activity
   • Chemoattractant for monocytes
   • Prevents glucocorticoid-induced apoptosis in some T cell lines

SLC/TCA-4/Exodus-2
(secondary lymphoid-tissue chemokine, SLC)

1. Receptor
   • Unknown
2. Cell source
   • Thymic epithelial cells
   • Lymph node
   • Appendix and spleen
3. Cell target
   • T cells
4. Biologic activity
   • Chemoattractant for T lymphocytes
   • Inhibits hematopoiesis

DC-CK1/PARC
(dendritic cell-specific CC-chemokine 1, DC-CK1)
(pulmonary and activation-regulated chemokine, PARC)

1. Receptor
   • Unknown
2. Cell source
   • Dendritic cells in secondary lymphoid tissues
3. Cell target
   • Naïve T cells
4. Biologic activity
   • May have a role in induction of immune responses

TECK (thymus-expressed chemokine)

1. Receptor
   • Unknown
2. Cell source
   • Dendritic cells
   • Thymus
   • Liver
   • Small intestine
3. Cell target
   • T cells
   • Monocytes/macrophages
   • Dendritic cells
4. Biologic activity
   • Thymic dendritic cell-derived cytokine
   • Possibly involved in T cell development

GRO-α/MGSA
(growth-regulated oncogene, GRO)
(melanoma growth stimulatory activity, MGSA)

1. Receptor
   • CXCR2
2. Cell source
   • Activated granulocytes
   • Monocytes/macrophages
   • Epithelial cells
3. Cell target
   • Neutrophils
   • Epithelial cells
   • Endothelial cells
4. Biologic activity
   • Neutrophil chemoattractant and activator
   • Mitogenic for some melanoma cell lines
   • Suppresses proliferation of hematopoietic precursors
   • Angiogenic activity

GRO-β/MIP-2α
(macrophage inflammatory protein, MIP)

1. Receptor
   • CXCR2
2. Cell source
   • Activated granulocytes
   • Monocytes/macrophages
3. Cell target
   • Neutrophils
   • Endothelial cells
4. Biologic activity
   • Neutrophil chemoattractant and activator
   • Angiogenic activity

NAP-2 (neutrophil-activating peptide-2)

1. Receptor
   • CXCR2
2. Cell source
   • Platelets
3. Cell target
   • Neutrophils
   • Basophils
4. Biologic activity
   • Derived from platelet basic protein
   • Neutrophil chemoattractant and activator

IP-10 (interferon gamma-induced protein 10)

1. Receptor
   • CXCR3
2. Cell source
   • Monocytes/macrophages
   • T cells
   • Fibroblasts
   • Endothelial cells
   • Epithelial cells
3. Cell target
   • Activated T cells
   • Tumor infiltrating lymphocytes
   • Endothelial cells
   • NK cells
4. Biologic activity
   • Chemoattractant for T cells
   • Suppresses proliferation of hematopoietic precursors

MIG (monokine induced by gamma interferon)

1. Receptor
   • CXCR3
2. Cell source
   • Monocytes/macrophages
   • T cells
   • Fibroblasts
3. Cell target
   • Activated T cells
   • Tumor infiltrating lymphocytes
4. Biologic activity
   • Chemoattractant for T cells
   • Suppresses proliferation of hematopoietic precursors

SDF-1 (stromal cell derived factor 1)

1. Receptor
   • CXCR4
2. Cell source
   • Fibroblasts
3. Cell target
   • T cells
   • Dendritic cells
   • Basophils
   • Endothelial cells
4. Biologic activity
   • Low-potency, high-efficacy T cell chemoattractant
   • Required for B-lymphocyte development
   • Prevents infection of CD4⁺, CXCR4⁺ cells by T cell tropic HIV

Fractalkine

1. Receptor
   • CX₃CR1
2. Cell source
   • Activated endothelial cells
3. Cell target
   • NK cells
   • T cells
   • Monocytes/macrophages
4. Biologic activity
   • Cell-surface chemokine/mucin hybrid molecule that functions as a chemoattractant
   • Leukocyte activator
   • Cell adhesion molecule

PF-4 (platelet factor 4)

1. Receptor
   • Unknown
2. Cell source
   • Platelets
   • Megakaryocytes
3. Cell target
   • Fibroblasts
   • Endothelial cells
4. Biologic activity
   • Chemoattractant for fibroblasts
   • Suppresses proliferation of hematopoietic precursors
   • Inhibits endothelial cell proliferation and angiogenesis