大腸癌相關表格
|
成因 |
異常功能 |
基因 |
顯隱性 |
組織學 |
|
FAP (70%) |
APC/WNT pathway |
APC |
體顯性 |
Tubular, villous |
|
FAP (<10%) |
DNA mismatch repair |
MUTY |
體隱性 |
Sessile serrated adenoma |
|
HNC |
DNA mismatch repair |
MSH2, MLH1 |
體顯性 |
Sessile serrated adenoma |
|
Sporadic (80%) |
APC/WNT pathway |
APC |
Nil |
Tubular, villous |
|
Sporadic (15%) |
DNA mismatch repair |
MSH2, MLH1 |
Nil |
Sessile serrated adenoma |
FAP = Familial Adenomatous Polyposis
HNC = Hereditary Nonpolyposis Colorectal Cancer
Hereditary nonpolyposis colorectal cancer和Sporadic colon cancer (MSH2, MLH1)好發於右側大腸、Sporadic colon cancer (APC)好發於左側大腸
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